南予医学雑誌19巻

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大下、他：全自動血液凝固測定装置CS-2500におけるファクターオートP-FDP，Ｄダイマー試薬の基礎的検討およびFDP，Ｄダイマー測定値逆転現象の解析南予医誌　Vol.19　No. １　2019－27－Effects of the FDP and D-dimer plasma reagents on CS-2500 automatic blood clot analyzer data and analysis of the D-dimer-reversal phenomenonAbstract　Fibrin degradation product （FDP） and D-dimer assays are commonly used for evaluating fibrinolysis. However, the antigen-recognition sites, reactivity, and composition of antibodies （detection reagents） vary among manufacturers, creating differences in measurements and a lack of standardization. Use of the FDP plasma reagent in conjunction with the CS-2500 automatic blood clot analyzer kit, and the basic D-dimer reagent of the Q-May Laboratory Corporation, yielded data that correlated well with those yielded by control reagents; uniformity was apparent among different molecular species. However, when using the control reagents, FDP and D dimer reversal were evident in plasma specimens containing the D fraction. Therefore, the data must be interpreted with caution; if plasma reagent characteristics are well understood, they are of clinical utility and their use will facilitate further standardization.（Nan-yo Med J 2019; 19: 17-27.）Keywords: FDP, D dimer, fibrinolytic marker, standardizationTokihiro OHSHITA1), Miku KIRA1), Sayaka NAKAHIRA1),Eriko UOZUMI1), Kinpei AKAMATSU2), Yukie NISHIMOTO1)1) Department of Clinical Laboratory, Uwajima City Hospital2) Department of Infection Administration, Uwajima City Hospital