南予医学雑誌　第18巻

45/91

南予医誌　Vol.18　No. １　2017－44－patients might not be apparent in other area．Moreover， allergen-specific IgE is examined in no patients in this study．It is necessary to elucidate specic responses of the patients to the seasonal allergens．In conclusion， this study showed that se-rum IgE levels of Graves’ disease patients significantly increased in spring compared with those in summer， and in female Graves’ patients， serum IgE levels sig-nificantly increased in spring and autumn compared with those in summer．Measure-ments of allergen-specific IgE at the first visit and analysis for the changes of serum IgE levels are required in future．DisclosureThe authors declare that there are no com-peting nancial interests．References１）　 Hidaka Y， Masai T， Sumizaki H， et al．Onset of Graves’ thyrotoxicosis after an attack of allergic rhinitis．Thyroid 1996; 6: 349-351．２）　 Sato A， Takemura Y， Yamada T， et al．A possible role of immunoglobu-lin E in patients with hyperthyroid Graves’ disease．J Clin Endocrinol Metab 1999; 84: 3602-3605．３）　 Yamada T， Sato A， Komiya I， et al．An elevation of serum immunoglobu-lin E provides a new aspect of hyper-thyroid Graves’ disease．J Clin Endo-crinol Metab 2000; 85: 2775-2778．４）　 Komiya I， Yamada T， Sato A， et al．Remission and recurrence of hyper-thyroid Graves’ disease during and after methimazole treatment when assessed by IgE and interleukin 13．J Clin Endocrinol Metab 2001; 86: 3540-3544．５）　 Takeoka K， Hidaka Y， Hanada H， et al．Increase in serum levels of auto-antibodies after attack of seasonal al-lergic rhinitis in patients with Graves’ disease．Int Arch Allergy Immunol 2003; 132: 268-276．６）　 Hidaka Y， Amino N， Iwatani Y， et al． Recurrence of thyrotoxicosis af-ter attack of allergic rhinitis in patients with Graves’ disease．J Clin Endocri-nol Metab 1993; 77: 1667-1670．７）　 Umeki S． Allergic cycle: relation-ships between asthma， allergic rhini-tis， and atopic dermatitis． J Asthma 1994; 31: 19-26．８）　 Mimura T， Yamagami S， Amano S， et al．Allergens in Japanese patients with allergic conjunctivitis in autumn．Eye（Lond）2005; 19: 995-999．９）　 Mimura T， Usui T， Mori M， et al．Specific tear IgE in patients with moderate-to-severe autumnal allergic conjunctivitis．Int Arch Allergy Im-munol 2011; 156: 381-386．