南予医学雑誌　第18巻

68/91

青石、他：子宮体癌術後化学療法中に繰り返す偽膜性腸炎を呈した１例南予医誌　Vol.18　No. １　2017－67－A case of recurring pseudomembranous colitis during postoperative chemotherapy for endo-metrial cancer Abstract　Pseudomembranous colitis（PMC）is caused by Clostridium difficile infection; the bacteria grow rapidly and produce a toxin inhibiting the intestinal flora. PMC is usually attributable to antibacterial drug therapy. Here, we describe a case of repeated PMC during postoperative chemotherapy for endometrial cancer in the absence of antibacterial drug therapy.A 76-year-old female was diagnosed with an endometrioid adenocarcinoma, and underwent postoperative chemotherapy with doxorubicin and cisplatin after total abdominal hysterectomy and bilateral salpingo-oophorectomy. After the second drug course, she experienced frequent watery diarrhea at the times of neutropenia. She was diagnosed with PMC caused by toxin-positive Clostridium difficile, and metronidazole therapy was initiated. After the diarrhea improved, she underwent a third course of chemotherapy at reduced drug doses, but the PMC recurred. Although we then changed the anti-cancer agent to weekly taxotere and cyclophosphamide（TC）therapy, PMC recurred once more. We suggest that either neutropenia caused by chemotherapy or an effect of the anticancer agents on the intestinal flora triggered the PMC.（Nan-yo Med J 2017; 18: 62-67.）Keyword：Pseudomembranous colitisYuko AOISHI, Mari YANO, Masaki KIYOMURA, Mari IWAMOTO,Norihumi NAKAHASHIDepartment of GynecologyUwajima City HospitalGoten-machi, Uwajima, Ehime, 798-8510, Japan